Attenuation of the euphoric effects of cocaine
by the dopamine D1/D5 antagonist ecopipam
by
Romach MK, Glue P, Kampman K, Kaplan HL, Somer GR,
Poole S, Clarke L, Coffin V, Cornish J, O'Brien CP, Sellers EM
Psychopharmacology and Dependence Research Unit,
Centre for Research in Women's Health,
Sunnybrook and Women's College Health Sciences Centre,
Women's College Campus,
Toronto, Ontario,
Canada.
[email protected]
Arch Gen Psychiatry 1999 Dec;56(12):1101-6
ABSTRACTBACKGROUND: The subjective and reinforcing effects of cocaine in humans are associated with the enhancement of endogenous dopamine function in the mesolimbic system. This study examined the role of dopamine D1-like receptors in the behavioral and mood effects of cocaine by evaluating the effects of the selective D1/D5 antagonist ecopipam (SCH 39166) on subjective responses to intravenous cocaine in 11 subjects with cocaine dependence as defined by DSM-IV. METHODS: Subjects were pretreated in a randomized double-blind fashion with either placebo or 10 mg, 25 mg, or 100 mg of ecopipam orally on 4 separate occasions. Two hours later a single intravenous injection of 30 mg of cocaine was administered. Subjective and cardiovascular responses were measured and blood samples for pharmacokinetic evaluation were obtained prior to cocaine dosing and at various times after dosing. RESULTS: The euphoric (P = .004) and stimulating (P = .03) effects of cocaine were attenuated in a dose-dependent manner by ecopipam, while ratings of desire to take cocaine were diminished (P = .02). Ecopipam in combination with cocaine was safe and well tolerated. CONCLUSION: These data indicate a potentially important role for D1-like receptors in the acute mood-altering and rewarding effects of cocaine in humans.Ecopipam
Supercoke
Ketoconazole
Dopaminergic flies?
Dopaminergic agents
GBR12909 and the rat
Cocaine immunization
The coke-craving brain
Cocaine and the lonely rat
Monoamines, cocaine and rats
Freebasing flies go hyperkinetic01 02 03 04 05 06 07 08 09 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24
Refs
HOME
HedWeb
cannabis-marijuana.com
Future Opioids
BLTC Research
Wirehead Hedonism
Paradise-Engineering
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best to Take Crack Cocaine?
The Good Drug Guide
The Responsible Parent's Guide To
Healthy Mood Boosters For All The Family
