Serotonin as an important mediator of cocaine's behavioral effects
by
Muller CP, Carey RJ, Huston JP.
Institute of Physiological Psychology I
and Center for Biological and Medical Research,
University of Dusseldorf,
Dusseldorf, Germany.
[email protected]
Drugs Today (Barc). 2003 Jul;39(7):497-511
ABSTRACTAlthough the dopaminergic system still plays an important role in the investigation of the behavioral effects of cocaine, a broad literature emerged parallel to this research that provided significant evidence for an important contribution of the serotonergic (5-hydroxytryptamine, 5-HT) system. It has been known for a long time that the 5-HT transporter is one of the primary targets of cocaine within the brain and that cocaine causes an increase in the 5-HT activity in many brain regions. In general, the 5-HT system plays an important role in the organization of spontaneous behaviors, like locomotion, eating, drinking or grooming, and is also involved in emotion and mood. This review provides an overview of the role of 5-HT and 5-HT receptors in the acute behavioral and subjective effects of cocaine. There is broad evidence for a contribution of the 5-HT system to cocaine-induced hyperactivity in animals and to the subjective hedonic effects in humans. Studies with selective 5-HT receptor-ligands suggest the contribution of a large number of different 5-HT receptor subtypes to these effects. In order to fully understand the behavioral effects of cocaine and the mechanisms of their mediation, the 5-HT system needs to be considered, either parallel to or in interaction with the dopaminergic system.5-HT3
5-HT1a
5-HT1b
5-HT2a
5-HT2c
Reward
Anxiety
Metabolism
Oral cocaine
Dopaminergic flies?
Dopaminergic agents
The coke-craving brain
Cocaine and depression
Cocaine and the lonely rat
Monoamines, cocaine and rats
01 02 03 04 05 06 07 08 09 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24
Refs
HOME
HedWeb
cannabis-marijuana.com
Future Opioids
BLTC Research
Wirehead Hedonism
Paradise-Engineering
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best to Take Crack Cocaine?
The Good Drug Guide
The Responsible Parent's Guide To
Healthy Mood Boosters For All The Family
