Individual differences in the subjective
response to smoked cocaine in humans
by
Sofuoglu M, Brown S, Dudish-Poulsen S, Hatsukami DK
Department of Psychiatry,
University of Minnesota,
Minneapolis 55455, USA.
[email protected]
Am J Drug Alcohol Abuse 2000 Nov; 26(4):591-602

ABSTRACT

The individual variables that determine the effects of cocaine in humans are not well understood. In this study, we examined the relationship between the subjective response to cocaine and selected individual variables in cocaine-dependent participants. A single 0.4-mg/kg dose of smoked cocaine was received by 75 smoked cocaine users. The variables associated with increased subjective response to cocaine were male sex, presence of alcohol use, higher baseline Beck Depression Inventory (BDI) scores, and duration of cocaine use. The change in heart rate and diastolic blood pressure in response to cocaine delivery were also positively associated with the subjective response to cocaine. In contrast, body weight, years of schooling, and the change in the heart rate with the expectation of cocaine delivery were associated with a diminished subjective response to cocaine. The importance of these variables in maintaining the cocaine use behavior needs to be studied further.

History
Metabolism
Amantadine
Oral cocaine
Dopaminergic flies?
Dopaminergic agents
The coke-craving brain
Cocaine and depression
Cocaine and the lonely rat
Monoamines, cocaine and rats
Cocaine and artificial enzymes
Freebasing flies go hyperkinetic

01 02 03 04 05 06 07 08 09 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24

Refs
HOME
HedWeb
cannabis-marijuana.com
Future Opioids
BLTC Research
Wirehead Hedonism
Paradise-Engineering
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best to Take Crack Cocaine?

The Good Drug Guide
The Responsible Parent's Guide To
Healthy Mood Boosters For All The Family