Active cocaine immunization attenuates
the discriminative properties of cocaine
by
Johnson MW, Ettinger RH
Department of Psychology,
Eastern Oregon University,
La Grande 97850, USA.
Exp Clin Psychopharmacol 2000 May; 8(2):163-7
ABSTRACTAnticocaine antibody, resulting from immunization with the cocaine-keyhole-limpet-hemocyanin (KLH) conjugate, weakened the ability of cocaine to act as a discriminative stimulus in rats. Subjects were given extensive training to discriminate 5.0 mg/kg of cocaine from saline prior to immunization. Several weeks following immunization with cocaine-KLH, subjects failed to reliably discriminate cocaine from saline. Nonimmunized control rats retained the ability to discriminate cocaine from saline throughout the experiment. These results further demonstrate that active immunization is effective in blunting cocaine effects. Immunized subjects were able to discriminate 20 mg/kg of cocaine, however, suggesting that anticocaine antibody may be overwhelmed by large cocaine doses.CART
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